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November 23, 2021

49ers vs Titans Odds, Spreads & Betting Lines – Sports Betting

American Football

49ers vs. Titans Odds

The San Francisco 49ers and the Tennessee Titans don’t have much history. The two teams met each other only 14 times between 1970 and 2017. 

The 49ers already have five Super Bowl titles, while the Titans are still hoping for one. As the 2021 NFL regular season starts, what are the odds of these two squads getting into the playoffs? 

Will the 49ers wear the Super Bowl ring again? Or will the Titans finally end their championship drought? If you want to be updated on their journey, you’re in the right place. 

This article includes the 49ers-Titans’ previous matches, their stats last season, and the betting trends. is a licensed online sportsbook that strives to give bettors of all kinds the latest NFL betting odds. We have a geolocation feature and identity verification process, so you can be confident that your info is kept safe and private.  

49ers vs. Titans: All-Time Series 

December 25, 1993: On Christmas Day, the Titans, then the Houston Oilers, won their tenth consecutive game when they defeated the San Francisco 49ers. The final scores were 10-7. 

November 8, 2009:  Vince Young’s courageous play as quarterback gave Tennessee a much-needed morale boost after a 0-6 start in their matchup against the 49ers. His gritty performance led to the Titans’ back-to-back victories.

Tennessee’s Chris Johnson made an 81-yard touchdown but was overturned. Six plays after, he took a pitch from Young and scurried two YDS (passing yards) for a go-ahead score. 

Young and Johnson led the Tennessee Titans to their second straight win. The final scores were 34-27.  

October 20, 2013: Colin Kaepernick of the 49ers threw for 199 YDS and ran for 68 and a TD (touchdown). He helped the 49ers start a two-game road swing when they beat the Titans, 31-17. 

San Francisco won their fourth straight game before heading to London for a matchup against the Jacksonville Jaguars.  

49ers vs. Titans: Stats Last Season 

2017 NFL Week 15 

San Francisco’s Jimmy Garoppolo made one last scoring drive to secure a fantastic first home start in the closing seconds.   

Fellow 49ers Robbie Gould kicked a game-winning 45-yard field goal that led to San Francisco’s victory over Tennessee, 25-23. 

Garoppolo tossed a career-high 381 YDS and a TD during the matchup to give the 49ers a three-game winning streak. Meanwhile, Gould placed the Niners out front on a 48-yarder with 3:08 left. 

On the other hand, Marcus Mariota drove Tennessee to a lead (8-6) as fellow Titans Ryan Succop kicked a 50-yard field goal with only 1:07 remaining. Despite Tennessee’s efforts to steal the play, Garoppolo and the Niners still triumphed in the end.  

Though it took three tries, coach Kyle Shanahan finally found a reliable quarterback after picking Jimmy Garoppolo from the Patriots during the October trade deadline. 

Garoppolo made the first Niners QB win each of his first three starts since the AFL-NFL merger in 1970.  

49ers vs. Titans: Betting Trends

2017 NFL Week 15

Point Spread 

The Niners opened as six-point favorites. The total was 38.5. San Francisco also covered the spread in the team’s previous matchups. 


  • The Titans were 6-0-1 against the spread in seven games vs. San Francisco since 1987.
  • The 49ers were 5-1 against the spread as a road favorite. 

How to Bet 

You can bet on the moneyline if you think either the Niners or Titans can win straight up. A minus (-) sign represents the favored team to win the game, while a plus (+) sign represents the underdog. 

Other betting options you can try are the following:

  1. Point Spread
  2. Point Total (Over/Under)
  3. In-Play and Live Betting
  4. Parlays and Teasers 

Click here to understand NFL odds better. 

Where to Watch 

The NFL offers free live streaming and podcast episodes on mobile devices. Most networks, such as CBS, NBC, ESPN, and FOX, cover the league. 

Below is the complete list of the NFL teams:

AFC East AFC North AFC South AFC West NFC East NFC North NFC South  NFC West
Buffalo Bills Pittsburgh Steelers Tennessee Titans Kansas City Chiefs Washington Football Team Green Bay Packers New Orleans Saints Seattle Seahawks
Miami Dolphins Baltimore Ravens Indianapolis Colts Las Vegas Raiders New York Giants Chicago Bears Tampa Bay Buccaneers Los Angeles Rams
New England Patriots Cleveland Browns Houston Texans Los Angeles Chargers Dallas Cowboys Minnesota Vikings Carolina Panthers Arizona Cardinals
New York Jets Cincinnati Bengals Jacksonville Jaguars Denver Broncos Philadelphia Eagles Detroit Lions Atlanta Falcons San Francisco 49ers

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