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November 23, 2021

Colts vs Cardinals Odds, Spreads & Betting Lines – Sports Betting

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Colts vs. Cardinals Odds 

The Arizona Cardinals are the oldest squad in the NFL. However, they have only had one Super Bowl appearance in 2009. That said, most websites rank it as one of the top Super Bowls of all time. 

Meanwhile, the Indianapolis Colts won two Super Bowls in 1971 and 2007. Both NFL teams hope to end their championship drought. Can either squad do it in the 2021 NFL season?

This article includes the Colts-Cardinals’ previous matches, their stats last season, and the betting trends. is an online sportsbook dedicated to giving bettors the best odds and lines. We have an identity verification process, so you can be sure your info is kept safe.  

Colts vs. Cardinals: All-Time Series 

Below are the Colts-Cardinals game series between 1996 and 2017:

Date Visitor Home Result 
09/17/2017 Arizona Cardinals Indianapolis Colts  16-13
11/24/2013 Indianapolis Colts  Arizona Cardinals  11-40
09/27/2009 Indianapolis Colts  Arizona Cardinals  31-10
01/01/2006 Arizona Cardinals  Indianapolis Colts  13-17
09/01/1996 Arizona Cardinals  Indianapolis Colts  13-20

Colts-Cardinals: November 2013 Blowout Win

The Arizona Cardinals made a statement when they defeated the Indianapolis Colts, 40-11. 

With a 7-4 standing, the Cardinals stayed in serious contention for a wild card playoff berth. The Arizona Cardinals proved their playoff worthiness when they beat the Colts at home. 

The Cardinals made an explosive first half by ending it with double-digit points. Arizona led 27-3 at the end of the first half, while their quarterback finished 15 of 20 for 191 YDS (passing yards) and two touchdowns (TDs).  

The ball landed in the hands of Arizona’s wide receiver Larry Fitzgerald. He also beat two Colts players to the end zone. 

The Colts’ offense was weak in the third quarter. Though Indy made its first TD with 10:26 left plus a two-point conversion, its score was still behind by 23 points. 

Colts vs. Cardinals: Stats Last Season

2017 NFL Week 2 

Arizona’s Carson Palmer made a late rally that pushed the Colts-Cardinals game into overtime. His teammate, Tyrann Mathieu, also made interceptions that set up fellow Cardinals Phil Dawson for a 30-yard field goal. 

Dawson pushed a 42-yarder wide right as time expired. The Cardinals (1-1) never led until the final play. 

The Colts were 0-2 for the fourth consecutive year. Indy’s quarterback, Jacoby Brissett, led the Colts to a TD on their first drive. He also made a field goal on the second drive. 

Unfortunately, Indy’s inability to move the offense helped Arizona’s Palmer get in sync. The Cardinals won the game via OT, 16-13. 

Colts vs. Cardinals: Betting Trends

2017 NFL Week 2 

Point spread: Arizona opened as 2.5-point favorites.

Totals: 44.5 

Why the Indianapolis Colts Could Cover the Spread 

The rushing game continued to save the day for the Colts. Although Andrew Luck was difficult to protect on the field, the Indy’s rushing game was promising, so it could be the key against the Cardinals’ defense.   

Why the Arizona Cardinals Could Cover the Spread 

The Cardinals had a 6-4 standing. They tied for second place in the NFC West with the San Francisco 49ers. Arizona also ranked as the ninth defense team in the league. 


  1. The Colts and the Cardinals have played five straight “under” games since 1990.
  2. Indianapolis won the past four meetings straight up. 

How to Bet 

Moneyline is the most straightforward bet you can try. It presents the odds in an American-style format using a plus (+) or minus (-) sign to show how each side will pay. 

The favorite team in the moneyline is the one perceived to be a stronger contender. A minus (-) sign represents it. Meanwhile, the underdog is the team that is predicted to lose. A plus (+) sign is attached to the number representing its odds.   

You can also try betting on player props that revolve around an individual player’s performance. You can back the Cards’ Kyler Murray for MVP if you’re confident that he’ll win.  

Other betting options you can try are as follows:

  • Totals or Over/Under Bet
  • Point Spread
  • In-play and Live Betting
  • Parlays and Teasers 

Click here to get a glimpse of NFL odds. 

Where to Watch 

The NFL offers podcast episodes and free live streaming on mobile devices. Most networks, such as NBC, CBS, FOX, and ESPN, also cover the league. 

Below is the complete list of the NFL football teams:

AFC East AFC North AFC South AFC West NFC East NFC North NFC South  NFC West
Buffalo Bills Pittsburgh Steelers Tennessee Titans Kansas City Chiefs Washington Football Team Green Bay Packers New Orleans Saints Seattle Seahawks
Miami Dolphins Baltimore Ravens Indianapolis Colts Las Vegas Raiders New York Giants Chicago Bears Tampa Bay Buccaneers Los Angeles Rams
New England Patriots Cleveland Browns Houston Texans Los Angeles Chargers Dallas Cowboys Minnesota Vikings Carolina Panthers Arizona Cardinals
New York Jets Cincinnati Bengals Jacksonville Jaguars Denver Broncos Philadelphia Eagles Detroit Lions Atlanta Falcons San Francisco 49ers

Sports betting is an exciting endeavor. Visit to know the latest betting odds for the Colts vs. Cardinals matchup.